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Decongestant Drug Interactions: What You Need to Know

 
How will decongestants interact with other kinds of drugs?

How will decongestants interact with other kinds of drugs?

Before taking any new medication, let your doctor know what other drugs and supplements - both prescription and over-the-counter medications - you take.

The following medications can make decongestant side effects worse:

  • antibiotics and antifungal medications
  • antidepressants such as monoamine oxidase inhibitors (MAOIs such as Parnate and Nardil) and tricyclic antidepressants or TCAs, in general
  • blood pressure or heart medications, such as beta-blockers, guanethidine, methyldopa, and rauwolfia
  • nonsteroidal anti-inflammatory drugs such as indomethacin for arthritis

Nasal decongestants can alter the effects of the following types of medications:

  • anti-Parkinson agents, such as bromocriptine mesylate
  • blood pressure or heart medications, such as beta-blockers
  • caffeine products such as coffee, tea, or colas
  • insulin or oral hypoglycemic agents, used for elevated blood glucose and diabetes
  • antipsychotic drugs in general
  • theophylline taken for respiratory problems
  • urinary acidifiers or alkalinizers taken for bladder problems